Frequency of the OCTN-TC haplotype and of the IGR2078a_1A risk associated allele stratified by clinical phenotype of Crohn’s disease
| Subgroup | No of individuals (n = 412) | Frequency of the TC haplotype (%) | Significance v controls (p value*; OR (95% CI)) | Frequency of IGR2078a_1A (%) | Significance v controls (p value*; OR (95% CI)) |
|---|---|---|---|---|---|
| *p values given were significant (p<0.05), also after application of Bonferroni’s correction. †Data were also analysed for isolated fistulising or fibrostenotic disease behaviour but no further significant association was noted. | |||||
| Disease location | |||||
| Ileal and no colonic | 50 | 40.0 | NS | 37.0 | NS |
| Colonic and no ileal | 62 | 50.8 | NS | 49.1 | NS |
| Any colonic disease | 360 | 48.6 | 0.0025; 1.31 (1.10–1.55) | 47.5 | 0.0089; 1.29 (1.26–1.57) |
| Disease behaviour | |||||
| Any fistulising† | 223 | 46.9 | NS | 45.7 | NS |
| Any fibrostenotic† | 262 | 46.4 | NS | 45.0 | NS |
| Non-fistulising non-fibrostenotic | 92 | 53.3 | 0.0040; 1.57 (1.15–2.15) | 52.2 | 0.0056; 1.56 (1.13–2.14) |
| Need for surgery | |||||
| Ileocaecal resection | 144 | 43.1 | NS | 43.1 | NS |
| No ileocaecal resection | 268 | 50.0 | 0.0011; 1.38 (1.14–1.68) | 48.3 | 0.0048; 1.33 (1.09–1.63) |