Table 4

 Frequency of the OCTN-TC haplotype and of the IGR2078a_1A risk associated allele stratified by clinical phenotype of Crohn’s disease

SubgroupNo of individuals (n = 412)Frequency of the TC haplotype (%)Significance v controls (p value*; OR (95% CI))Frequency of IGR2078a_1A (%)Significance v controls (p value*; OR (95% CI))
*p values given were significant (p<0.05), also after application of Bonferroni’s correction. †Data were also analysed for isolated fistulising or fibrostenotic disease behaviour but no further significant association was noted.
Disease location
    Ileal and no colonic5040.0NS37.0NS
    Colonic and no ileal6250.8NS49.1NS
    Any colonic disease36048.60.0025; 1.31 (1.10–1.55)47.50.0089; 1.29 (1.26–1.57)
Disease behaviour
    Any fistulising†22346.9NS45.7NS
    Any fibrostenotic†26246.4NS45.0NS
    Non-fistulising non-fibrostenotic9253.30.0040; 1.57 (1.15–2.15)52.20.0056; 1.56 (1.13–2.14)
Need for surgery
    Ileocaecal resection14443.1NS43.1NS
    No ileocaecal resection26850.00.0011; 1.38 (1.14–1.68)48.30.0048; 1.33 (1.09–1.63)