Association of nodal metastasis, matrilysin expression, and type of therapy with clinicopathological parameters of pT1 colon and rectal cancer (CRC)
| Variable | Category (n = 180) | Node positive (n = 20) | Node negative (n = 160) | p Value | Matrilysin expression | p Value | Surgical (n = 94) | EMR (n = 86) | p Value | |
|---|---|---|---|---|---|---|---|---|---|---|
| Positive (n = 56) | Negative (n = 124) | |||||||||
| *Comparison of age and tumour size (mean (SD)) in the two groups was examined using the Student’s t test. | ||||||||||
| †Submucosal invasion was divided into two levels, scanty (200–300 μm distance from muscularis mucosa) and massive. | ||||||||||
| ‡This variable was analysed by the exact p value based on Pearson’s statistics. | ||||||||||
| ¶β-Catenin was examined in 141 of 180 cases. | ||||||||||
| EMR, Endoscopic mucosal resection. | ||||||||||
| Age* | 62.5 (9.6) | 61.8 (8.2) | 62.6 (9.8) | 0.699 | 62.3 (10.0) | 62.5 (9.5) | 0.891 | 62.7 (9.8) | 62.3 (9.4) | 0.816 |
| Sex | ||||||||||
| F | 52 (28.9) | 8 (40.0) | 44 (27.5) | 0.296 | 19 (33.9) | 33 (26.6) | 0.375 | 29 (30.9) | 23 (26.7) | 0.622 |
| M | 128 (71.1) | 12 (60.0) | 116 (72.5) | 37 (66.1) | 91 (73.4) | 65 (69.1) | 63 (73.3) | |||
| Size of tumour* | 17.5 (8.8) | 16.2 (7.9) | 17.6 (8.9) | 0.443 | 18.8 (10.2) | 16.9 (8.0) | 0.215 | 20.0 (9.5) | 14.7 (6.9) | 0.0004 |
| Depth of invasion† | ||||||||||
| Scanty | 49 (27.2) | 1 (5.0) | 48 (30.0) | 0.016 | 8 (14.3) | 41 (33.1) | 0.011 | 29 (30.9) | 20 (23.3) | 0.315 |
| Massive | 131 (72.8) | 19 (95.0) | 112 (70.0) | 48 (85.7) | 83 (66.9) | 65 (69.1) | 66 (76.7) | |||
| Location | ||||||||||
| Right sided | 55 (30.6) | 3 (15.0) | 52 (32.5) | 0.274 | 16 (28.6) | 39 (31.5) | 0.320 | 33 (35.1) | 22 (25.6) | 0.119 |
| Left sided | 68 (37.8) | 9 (45.0) | 59 (36.9) | 18 (32.1) | 50 (40.3) | 29 (30.9) | 39 (45.3) | |||
| Rectum | 57 (31.7) | 8 (40.0) | 49 (30.6) | 22 (39.3) | 35 (28.2) | 32 (34.0) | 25 (29.1) | |||
| Histology‡ | ||||||||||
| Well | 141 (78.3) | 13 (65.0) | 128 (80.0) | 0.088 | 39 (69.6) | 102 (82.3) | 0.184 | 75 (79.8) | 66 (76.7) | 0.856 |
| Moderate | 37 (20.6) | 6 (30.0) | 31 (19.4) | 16 (28.6) | 21 (16.9) | 18 (19.1) | 19 (22.1) | |||
| Poor | 2 (1.1) | 1 (5.0) | 1 (0.6) | 1 (1.8) | 1 (0.8) | 1 (1.1) | 1 (1.2) | |||
| Nuclear β-catenin¶ | ||||||||||
| Negative | 41 (29.1) | 3 (23.1) | 38 (29.7) | NS | 16 (28.6) | 25 (20.2) | NS | 26 (28.6) | 15 (30.0) | NS |
| Positive | 100 (70.9) | 10 (76.9) | 90 (70.3) | 45 (71.4) | 55 (79.8) | 65 (71.4) | 35 (70.0) | |||
| Tumour budding | ||||||||||
| Negative | 49 (34.0) | 0 (0) | 49 (37.7) | 0.0025 | 2 (3.6) | 47 (55.3) | <0.0001 | 37 (39.4) | 12 (24.0) | NS |
| Positive | 95 (66.0) | 14 (100) | 81 (62.3) | 54 (96.4) | 41 (44.7) | 57 (60.4) | 38 (76.0) | |||
| Matrilysin expression | ||||||||||
| Negative | 124 (68.9) | 4 (20.0) | 120 (75.0) | <0.001 | 54 (57.4) | 70 (81.4) | 0.0066 | |||
| Positive | 56 (31.1) | 16 (80.0) | 40 (25.0) | 40 (42.6) | 16 (18.6) | |||||
| Lymphatic invasion | ||||||||||
| Negative | 137 (76.1) | 12 (60.0) | 125 (78.1) | 0.039 | 37 (66.1) | 100 (80.6) | 0.0188 | 65 (69.1) | 72 (83.7) | 0.0239 |
| Positive | 43 (23.9) | 8 (40.0) | 35 (21.9) | 19 (33.9) | 24 (19.4) | 29 (30.9) | 14 (16.3) | |||
| Venous invasion | ||||||||||
| Negative | 136 (75.6) | 8 (40.0) | 128 (80.0) | 36 (64.3) | 100 (80.6) | 0.01 | 66 (70.2) | 70 (81.4) | 0.861 | |
| Positive | 44 (24.4) | 12 (60.0) | 32 (20.0) | 20 (35.7) | 24 (19.4) | 28 (29.8) | 16 (18.6) | |||
| Nodal metastasis | ||||||||||
| Negative | 160 (88.9) | 40 (71.4) | 120 (96.8) | <0.0001 | 81 (86.2) | 79 (91.9) | 0.245 | |||
| Positive | 20 (11.1) | 16 (29.6) | 4 (3.2) | 13 (13.8) | 7 (8.1) | |||||