Table 3

 Association of nodal metastases and matrilysin expression with clinicopathological parameters of pT1–T4 colon and rectal cancer

VariableCategory (n = 244)Node positive (n = 122)Node negative (n = 122)p ValueMatrilysin expression
Positive (n = 176)Negative (n = 68)p Value
*Comparison of age and tumour size (mean (SD)) in the two groups was examined using the student’s t test.
†Depth of invasion was designated by “T”, referred to the local extent of the primary tumour in the TNM classification.
Age*65.0 (9.9)65.5 (9.9)64.5 (9.9)65.3 (9.8)64.0 (10.3)
Sex
    F94 (38.5)47 (38.5)47 (38.5)65 (36.9)29 (42.6)
    M150 (61.5)75 (61.5)75 (61.5)111 (63.1)39 (57.4)
Size of tumour*42.6 (24.4)48.2 (24.1)37.0 (23.4)0.0146.2 (22.4)33.5 (27.0)0.0003
Depth of invasion†
    pT156 (23.0)14 (11.5)42 (34.4)0.000822 (12.5)34 (50.0)0.0006
    pT222 (9.0)10 (8.2)12 (9.8)16 (9.1)6 (8.8)
    pT3115 (47.1)66 (54.1)49 (40.2)96 (54.5)19 (28.0)
    pT451 (20.9)32 (26.2)19 (15.6)42 (23.9)9 (13.2)
Location
    Right side77 (31.6)38 (31.1)39 (32.0)0.15454 (30.7)23 (33.8)0.789
    Left side80 (32.8)41 (33.6)39 (32.0)57 (32.4)23 (33.8)
    Rectum87 (35.7)43 (35.3)44 (36.0)65 (36.9)22 (32.4)
Differentiation grade
    Well113 (46.3)38 (31.1)75 (61.5)0.003471 (62.8)42 (61.8)0.012
    Moderate116 (47.5)72 (59.0)44 (36.1)93 (80.2)23 (33.8)
    Poor15 (6.1)12 (9.8)3 (2.4)12 (80.0)3 (4.4)
Lymphatic invasion
    Negative73 (29.9)9 (7.4)64 (52.5)0.000234 (46.6)39 (57.4)0.0001
    Positive171 (70.1)113 (92.6)58 (47.5)142 (83.0)29 (42.6)
Venous invasion
    Negative95 (38.9)32 (26.2)63 (51.6)0.000451 (53.7)44 (64.7)0.0004
    Positive149 (61.1)90 (73.8)59 (48.4)125 (83.9)24 (35.3)
Matrilysin expression
    Negative68 (27.9)11 (9.0)57 (46.7)0.0005
    Positive176 (72.1)111 (91.0)65 (53.3)
Nodal metastases
    Negative65 (36.9)57 (83.8)0.0005
    Positive111 (63.1)11 (16.2)