Table 3

 Microscopic findings in the pancreas

GroupOedemaInflammatory cell infiltrationFibrosisFatty changeTubular complex
Histological findings of chronic pancreatitis such as fibrosis, inflammatory cell infiltration, tubular complexes, and fatty changes were calculated as the sum of lesion size scores per rat. Lesion size scores were as follows : 0 = absent; 1 = lesion appearing slightly in the lobule or intralobular region; 3 = lesion evident across the lobule and intralobular region or showing destruction of lobular architecture.
DBTC, dibutyltin dichloride; mMCP-1, mutant monocyte chemoattractant protein 1.
Values are means (SEM) (n = 5).
Significant differences: **p<0.01, mMCP-1 treated group versus DBTC treated group on days 14 and 28.
DBTC+empty plasmid (14 days)0.6 (0.2)2.3 (0.3)2.1 (0.2)1.4 (0.2)2.0 (1.6)
DBTC+mMCP-1 (14 days)0.3 (0.3)1.7 (0.2)1.6 (0.1)1.1 (0.2)1.5 (0.2)
DBTC+empty plasmid (28 days)02.8 (0.2)**2.7 (0.2)**1.6 (0.1)**2.8 (0.1)**
DBTC+mMCP-1 (28 days)01.3 (0.1)**1.3 (0.1)**0.6 (0.1)**1.0 (0.2)**