Time | Serum IL-8 (ng/ml) | Fold induction v baseline† |
---|---|---|
*Serum IL-8 was measured by ELISA in FABP-rtTA × TRE2IL-8 mice before treatment with DOX (day 0) or 2 and 5 days after initiation of DOX treatment. The results are expressed as the mean (SD) of three mice per group. A similar degree of IL-8 induction was obtained in two additional experiments of the same type. | ||
†The induction ratio is the ratio of serum IL-8 in DOX-induced FABP-rtTA × TRE2IL-8 mice to uninduced double transgenic mice. | ||
Day 0 | 71 (20) | 1.0 |
Day 2 | 266 (101) | 3.7 |
Day 5 | 489 (47) | 6.9 |