Incidence rates of colorectal cancer (CRC) in the different study cohorts (number of cases per 100 patients per year)
| Characteristic | 5-ASA IBD cohort | Sulfasalazine RA cohort | Reference cohort (no 5-ASA use or IBD) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No of cases | Rate | Age/sex adjusted RR (95% CI) | No of cases | Rate | Age/sex adjusted RR (95% CI) | No of cases | Rate | Age/sex adjusted RR (95% CI) | |
| 5-ASA, 5-aminosalicylate; IBD, inflammatory bowel disease; RA, rheumatoid arthritis; RR (95% CI), relative risk (95% confidence interval). | |||||||||
| Overall | 124 | 0.17 | 1.99 (1.54–2.56) | 69 | 0.12 | 1.26 (0.94–1.70) | 116 | 0.09 | Reference |
| Age (y) | |||||||||
| 18–34 | 7 | 0.04 | 1 | 0.01 | 1 | <0.01 | |||
| 35–49 | 29 | 0.12 | 7 | 0.05 | 6 | 0.02 | |||
| 50–64 | 39 | 0.22 | 12 | 0.06 | 35 | 0.10 | |||
| 65–79 | 38 | 0.30 | 39 | 0.27 | 58 | 0.21 | |||
| 80+ | 11 | 0.49 | 10 | 0.61 | 16 | 0.37 | |||
| Women | 55 | 0.14 | 41 | 0.11 | 58 | 0.08 | |||
| Men | 69 | 0.19 | 28 | 0.14 | 58 | 0.11 | |||