Table 3

 Effects of liposome encapsulated oligonucleotides (ODNs) on macroscopic appearance in the colon of trinitrobenzene sulphonic acid treated animals

Parameter (range)ControlrAS3(0)rAS3(0/3)rScr(0)rAS3(3)rScr(3)
Abbreviations indicate the different treatment regimes as follows: rAS3, CD40 antisense ODN; rScr, scrambled control ODN; 0, treated at four hours prior to colitis induction on day 0; 3, treated on the third day post colitis induction.
Values are mean (SD) score values rounded to one decimal.
**p<0.01 versus control.
Diarrhoea (0–2)0.1 (0.4)0.0 (0.0)0.0 (0.0)0.4 (0.5)0.2 (0.4)0.3 (0.5)
General condition (0–1)0.3 (0.3)0.0 (0.0)0.0 (0.0)0.0 (0.0)0.0 (0.0)0.3 (0.5)
Adhesions (0–3)2.1 (0.6)1.0 (0.5)**1.3 (1.0)2.1 (0.7)1.3 (1.0)2.0 (0.6)
Perforation (0–1)0.3 (0.5)0.0 (0.0)0.3 (0.5)0.4 (0.5)0.2 (0.4)**0.8 (0.4)
Necrosis (0–4)2.9 (0.6)1.3 (1.3)**1.8 (0.8)**3.4 (0.5)1.8 (0.8)2.7 (0.8)
Ulceration (0–4)3.6 (0.5)2.5 (0.5)**2.3 (0.5)**3.9 (0.4)1.7 (0.8)**3.7 (0.8)
Oedema (0–1)1.0 (0.0)1.0 (0.0)0.8 (0.4)1.0 (0.0)0.8 (0.4)1.0 (0.0)
Megacolon (0–1)0.3 (0.5)0.1 (0.4)0.0 (0.0)0.3 (0.5)0.0 (0.0)0.2 (0.4)
Total score10.6 (2.3)5.9 (2.2)**6.7 (2.6)**11.6 (2.4)6.0 (3.0)**11.0 (2.9)
No of animals886766