Table 4

 Regular 5-aminosalicylate (5-ASA) use in the year before and risk of colorectal cancer (CRC)

Use of 5-ASANo of cases (n = 100)No of controls (n = 600)Crude OR (95% CI)Adjusted OR* (95% CI)
*Adjusted odds ratios (ORs) are based on multivariate logistic regression models including body mass index, duration of inflammatory bowel disease (IBD), history of colorectal polyps, use of non-steroidal anti-inflammatory drugs, paracetamol, aspirin, immunosuppressants, oral and rectal glucocorticoids, prior gastrointestinal hospitalisation, recorded colonoscopy, and number of general practitioner visits for IBD symptoms 6–24 months before.
†65 patients had less than two years of retrospective information prior to the index date and were included separately into the model.
‡Total number of 5-ASA prescriptions given at any time before the index date.
¶Based on the prescribed daily dose of the last 5-ASA prescription recorded prior to the index date.
95% CI, 95% confidence interval.
Irregular use 0–12 months before54265ReferenceReference
Regular use 0–12 months before463350.67 (0.44–1.03)0.60 (0.38–0.96)
    Sulfasalazine221370.77 (0.45–1.34)0.67 (0.36–1.25)
        6–12 Rx before‡3121.30 (0.35–4.80)0.95 (0.22–4.11)
        13–30 Rx before5530.45 (0.17–1.23)0.41 (0.14–1.20)
        >30 Rx before14720.91 (0.47–1.75)0.77 (0.37–1.60)
        Daily dose <2 g¶6320.93 (0.36–2.38)0.84 (0.29–2.42)
        Daily dose ⩾2 g¶15930.81 (0.43–1.51)0.69 (0.35–1.37)
    Mesalazine201860.51 (0.30–0.89)0.48 (0.27–0.88)
        6–12 Rx before‡10441.15 (0.54–2.44)1.13 (0.49–2.59)
        13–30 Rx before5710.34 (0.13–0.88)0.30 (0.11–0.83)
        >30 Rx before5710.32 (0.12–0.83)0.31 (0.11–0.84)
        Daily dose <1.2 g¶1150.32 (0.04–2.51)0.28 (0.03–2.27)
        Daily dose ⩾1.2 g¶191550.59 (0.34–1.05)0.56 (0.31–1.03)
    Other 5-ASA type4121.74 (0.55–5.56)1.38 (0.37–5.08)
No use 12–24 months before†2086ReferenceReference
Irregular use 12–24 months before311830.75 (0.40–1.40)0.70 (0.35–1.41)
Regular use 12–24 months before352800.54 (0.30–0.97)0.51 (0.26–0.99)