Details of pathogenic β-catenin mutations detected
| Tumour type | Mutation (n) | Amino acid change |
|---|---|---|
| One non-pathogenic mutation (GGA→GTA; G34V) was identified in a sporadic adenoma and one non-pathogenic mutation (ACC→GCC; H36P) in a sporadic cancer. | ||
| HNPCC, hereditary non-polyposis colorectal cancer. | ||
| Sporadic adenoma | del codon 24–38 (1) | ΔHWQQQSYLDSGIHSG |
| Family history adenoma | del codon 25–32 (1) | ΔWQQQSYLD |
| HNPCC adenoma | ACC→GCC (1) | T41A |
| HNPCC cancer | ACC→ATC (1) | T41I |
| HNPCC cancer | ACC→GCC (3) | T41A |
| HNPCC cancer | TCT→TTT (4) | S45F |