Characteristics of four patients with markedly symptomatic bile salt malabsorption resistant to antidiarrhoeal agents and intolerant of cholestyramine given colesevelam
| Age (y) | Sex | Reason for bile salt malabsorption | Outcome with cholestyramine | Outcome with colesevelam | Duration of colesevelam treatment (months) | Current dose of colesevelam |
|---|---|---|---|---|---|---|
| 37 | M | Idiopathic | Diarrhoea improved but not tolerated because it induced severe dyspepsia | Diarrhoea resolved, no side effects | 7 | 3.75 g/day |
| 59 | F | Right hemicolectomy | Diarrhoea improved but not tolerated due to unpalatability | Diarrhoea resolved, no side effects | 3 | 3.75 g/day |
| 68 | F | Radiation enteritis and right hemicolectomy | Diarrhoea improved although suffered intractable vomiting | Diarrhoea resolved, no side effects | 2 | 2.5 g/day |
| 40 | F | Radiation enteritis | Diarrhoea improved although suffered intractable nausea | Diarrhoea resolved, no side effects | 2 | 1.25 g/day |