Table 2

 Twenty two genes differentially expressed more than fourfold (p<0.01), comparing normal mucosa to matched Dukes’ B or C adenocarcinomas of the caecum

Probe set IDGene nameSymbolUG clusterCyto bandNcae med*IQ N†Bcae med‡IQ BCcae med§IQ CAvg FC¶ NvBAvg FC NvCp Value
*Ncae med, median derived from “signal” of 10 normal mucosae of the caecum.
†IQ interquartile, difference between the 75th and 25th percentiles.
‡Bcae med, median derived from “signal” of five Dukes’ B adenocarcinomas of the caecum.
§Ccae med, median derived from “signal” of five Dukes’ C adenocarcinomas of the caecum.
¶FC, fold change, corresponding to the “signal ratio” of Ncae med/Bcae med or Ncae med/Ccae med, was calculated from “the signal log ratio”.
UG cluster, UniGene cluster (http://www.ncbi.nlm.nih.gov/UniGene).
AF001548_rna1_atChromosome 16 BAC cloneHs.7834416p13.131165143799125261118−8.0−5.80.000
D10667_s_atSmooth muscle myosin heavy chain771531831818−10.2−11.20.000
J03507_atComplement protein component C7C7Hs.780655p1388161010118−6.4−4.60.000
J05096_rna1_atNaK-ATPase alpha 2 (ATP1A2)Hs.341141q21–q231574395−5.5−1.20.002
M14539_atCoagulation factor XIII, A1 polypeptideF13A1Hs.804246p25.31596042595211−4.6−3.10.000
M63379_atTRPM-2 protein gene9181022285328255144−5.1−4.00.000
M63603_atPhospholambanPLNHs.850506q22.12919762012−7.1−1.40.003
M77349_atTransforming growth factorTGFBIHs.1187875q3125311858265419331992.15.90.003
S67156_atAspartoacylase (aminoacylase 2)ASPAHs.3204217pter25107627−5.0−4.40.000
U18018_atEts variant gene 4ETV4Hs.7771117q21673334092261793.34.40.000
U20758_rna1_atOsteopontinHs.3134q21–q25152801281202984.612.80.000
U37283_atMicrofibril associated glycoprotein-2MAGP2Hs.5888212p13.15328171079−6.2−2.50.008
U70663_atKruppel-like factor 4; hEZFKLF4Hs.79349q315873951241277134−3.0−10.30.001
U71207_atEyes absent (Drosophila) homologue 2EYA2Hs.2927920q13.14436204641.1−6.40.016
U77180_atSmall inducible cytokine subfamily ASCYA19Hs.500029p13104503737−10.4−13.60.002
X00371_rna1_atMyoglobin gene (exon 1)Hs.11883622q13.121312044326548−7.1−3.40.000
X03350_atAlcohol dehydrogenase 1B (class I)ADH1BHs.44q21–q23854312553−9.0−17.20.000
X05232_atMMP3/stromelysin 1MMP3Hs.8332611q22.312101659624354415.533.60.000
X07820_atMMP10/stromelysin 2MMP10Hs.225811q22.3442842201010.17.10.001
X54162_atLeiomodin 1 (smooth muscle)LMOD1Hs.793861126842111369−5.3−4.50.000
X54925_atMatrix metalloproteinase 1MMP1Hs.8316911q22.3105248120244192916.936.70.000
X65614_atS100 calcium binding protein PS100PHs.29624p161703041392133620873717.46.10.000