Effect of intravenous injection of corticotropin releasing factor (CRF) on hepatic surface perfusion and portal venous pressure in urethane anaesthetised rats
| Time after intravenous injection (minutes) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 15 | 30 | 45 | 60 | 75 | 90 | 105 | 120 | |
| Values are mean (SEM) of five rats per group. After a basal observation, saline vehicle or CRF (2 nmol) was injected intravenously. A change in pancreatic blood flow was monitored thereafter for 120 minutes. | |||||||||
| Change in hepatic surface perfusion (%) | |||||||||
| Saline | 100 (0) | 102 (3) | 99 (3) | 102 (3) | 99 (5) | 98 (6) | 99 (4) | 100 (4) | 101 (4) |
| CRF | 100 (0) | 101 (4) | 100 (4) | 101 (4) | 102 (4) | 99 (4) | 98 (3) | 101 (4) | 99 (3) |
| Portal venous pressure (cm H2O) | |||||||||
| Saline | 9.8 (0.3) | 9.9 (0.3) | 10.1 (0.2) | 9.8 (0.4) | 10.3 (0.4) | 10.0 (0.6) | 9.6 (0.4) | 10.2 (0.4) | 10.3 (0.5) |
| CRF | 9.9 (0.7) | 10.1 (0.4) | 9.8 (0.4) | 10.0 (0.3) | 10.1 (0.7) | 10.3 (0.4) | 9.8 (0.4) | 10.3 (0.6) | 9.6 (0.4) |