Clinical features of mutation positive and negative families
| Mutation positive | Mutation negative | p Value* | |
|---|---|---|---|
| CRC, colorectal cancer; NS, not significant. | |||
| *Mann-Whitney U test/χ2 test. | |||
| †Tested with and without endometrial cancer. | |||
| ‡Mean (median). | |||
| §Compared with number of CRC. | |||
| Families | 25 | 16 | |
| Patients (with tumours and colorectal adenomas) | 106 | 71 | |
| Patients with tumours only | |||
| Index CRC | 21 | 16 | |
| Non-index CRC | 74 | 35 | |
| Non-CRC | 27 | 14 | |
| Overall | 101 | 65 | |
| Sex (all patients with tumours and CRC adenoma) | |||
| Female | 50 | 33 | |
| Male | 56 | 38 | |
| Sex tumour patients only | |||
| Female | 48 | 31 | |
| Male | 53 | 34 | |
| Overall | 101 | 65 | NS |
| CRC patients | |||
| Female | 25 | 20 | |
| Male | 40 | 32 | |
| Overall | 65 | 52 | NS |
| Non-CRC patients | |||
| Female | 23 | 11 | |
| Male | 13 | 2 | |
| Overall | 36 | 13 | NS† |
| Age of onset | |||
| Index CRC | 37.6 (39)‡ | 49.7 (45) | 0.0024 |
| All CRC | 43.5 (41) | 54.8 (55) | <0.001 |
| All tumours | 45.5 (43) | 54.8 (56) | 0.022 |
| Family age | 42.2 (42) | 54.1 (54·5) | <0.001 |
| Tumours | |||
| CRC | 89 | 52 | |
| Extracolorectal | 52 | 15 | 0.025 |
| Endometrial | 14 | 3 | |
| Gastric | 7 | 3 | |
| Small bowel | 7 | 0 | |
| Breast | 6 | 0 | |
| Other | 18 | 8 | NS |
| Gastrointestinal | 105 | 55 | |
| Non-gastrointestinal | 36 | 11 | NS |
| Overall | 141 | 66 | |
| Localisation index CRC | |||
| Proximal | 13 | 3 | |
| Splenic flexure | |||
| Distal | 8 | 13 | 0.010 |
| Splenic flexure | |||
| Syn-/metachronic (patients) | |||
| CRC | 12 | 1 | 0.017 |
| Extracolorectal tumours | 17 | 0 | <0.001 |
| Colorectal adenomas | 6 | 9 | (0.084) |
| Colorectal adenoma | |||
| Patients | 10 | 13 | (0.067) |
| Polyps | 15 | 20 | 0.030§ |