Table 1

 Number of patients studied and Toll-like receptor 4 Asp299Gly allele and genotype frequencies in Crohn’s disease (CD), ulcerative colitis (UC), and healthy control (HC) populations from Leuven, Munich, and Edinburgh

Patient numbers (allele frequencies)Crohn’s disease genotype frequencies
CDUCHCWild-typeHeterozygousHomozygous
HC allele frequencies differed between Edinburgh and Munich (p<0.02, odds ratio 1.35 (confidence interval 1.1–4.5)) and those between Edinburgh and Leuven approached significance (p = 0.06).
Leuven334 (11.0%)163 (10.0%)139 (5.0%)79.319.51.2
Munich102 (7.0%)98 (9.0%)145 (4.0%)85.015.00
Edinburgh234 (10.3%)246 (6.8%)189 (8.8%)79.519.70.8