Table 3

 Distribution of selected covariates according to alanine aminotransferase (ALT) flare, defined as a maximum value of ⩾400 IU/l or a maximum/minimum ALT ratio value of ⩾8

CovariatesALT flare (+):ALT flare (−)OR* (95% CI)
Odds ratios (ORs) and corresponding 95% confidence intervals (CI).
*Estimates from multiple logistic regression equations, including terms for age, sex, duration of hepatitis C virus, liver histology staging, modality of infection, basal values of ALT, number of observations, and genotype.
†Reference category.
‡Mean of the first three values.
§Not adjusted by liver histology staging.
Age (y)
    <4510:471†
    45–499:311.34 (0.42–4.28)
    50–548:361.45 (0.44–4.75)
    ⩾5512:531.31 (0.43–3.99)
Sex
    Males26:941†
    Females13:730.59 (0.24–1.44)
Modality of infection
    Community acquired29:1291†
    Parenteral10:381.20 (0.40–3.62)
Duration of hepatitis (y)
    <1018:791†
    10–197:351.00 (0.33–3.06)
    ⩾2014:531.22 (0.42–3.54)
Basal value of ALT‡
    <8015:521†
    80–1297:530.57 (0.17–1.89)
    ⩾13017:621.77 (0.61-5.12)
Histology grading of baseline biopsy§
    <819:841†
    8–1012:511.79 (0.62–5.11)
    ⩾113:180.84 (0.18–3.87)
    Missing5:14
Histology staging of baseline biopsy
    <325:751†
    3/45:320.34 (0.10–1.19)
    ⩾54:460.23 (0.06–0.88)
    Missing5:14