Table 3

 Definition of the Barcelona Clinic Liver Cancer (BCLC) staging for hepatocellular carcinoma

BCLC stagePSTTumour statusLiver function status
Tumour stageOkuda stage
Stages A and B: all criteria should be fulfilled.
Stage C: at least one criterion; *PST 1–2 or vascular invasion/extrahepatic spread.
Stage D: at least one criterion; †PST 3–4 or Okuda stage III/Child-Pugh C.
Stage A: early HCC0
    A10Single, <5 cmINo portal hypertension and normal bilirubin
    A20Single, <5 cmIPortal hypertension and normal bilirubin
    A30Single, <5 cmIPortal hypertension and abnormal bilirubin
    A403 tumours <3 cmI–IIChild-Pugh A–B
Stage B: intermediate HCC0Large multinodularI–IIChild-Pugh A–B
Stage C: advanced HCC1–2*Vascular invasion or extrahepatic spread*I–IIChild-Pugh A–B
Stage D: end stage HCC3–4†AnyIII†Child-Pugh C†