Table 2

 Protease activated receptors (PARs) and inflammatory bowel disease

PAR1 potential target for IBD treatments
Upregulated in the colon of CD and UC patientsUpregulated in the colon of UC patients
Activation causes colitis and increased permeabilityAcute activation causes colitis but chronic systemic activation is protective
Activation is involved in the pathogenesis of IBD animal models