Reductions in regional brain activation during stress and rectal pain with amitriptyline
| Brain region | BA | x,y,z | Cluster (voxel#) | Max T value | p Value cluster (set) | % of ROI reduced |
|---|---|---|---|---|---|---|
| BA, Brodman area; x,y,z, Talairach coordinates; Cluster, cluster size is number of voxels per cluster; T value, local maximum within the cluster (amitriptyline v placebo); p value, indicated for the individual cluster, (set) p value for the region of interest considering all clusters in the region, including those with individual p values >0.05. All clusters with p values ⩽0.1 are displayed; ROI, region of interest; ACC, anterior cingulate cortex; R, right; L, left. | ||||||
| Perigenual ACC | 24 | 6, 46, 8 | 62 | 3.34 | 0.05 (0.007) | 4.5 |
| L post parietal | 40 | 38, −36, 50 | 152 | 3.85 | 0.01 (0.07) | 4.5 |
| 46, −58, 44 | 208 | 3.57 | 0.003 | |||
| ACC cognitive | 24* | −4, 4, 34 | 69 | 3.58 | 0.08 (0.3) | 2.4 |
| R post parietal | 40 | −32, −54, 42 | 115 | 3.52 | 0.06 (0.16) | 1.5 |
| L hippocampus | 20, −56, 4 | 28 | 3.07 | 0.1 (0.054) | 1.7 | |