Family history characteristics of 732 patients presenting to the Leeds Teaching Hospitals with colorectal cancer, 1987–1999, with family history data and immunohistochemical results
| Total | Hospital series | Population series | p Value | |
|---|---|---|---|---|
| CRC, colorectal cancer; FDR, first degree relative; HNPCC, hereditary non-polyposis colorectal cancer; FH, family history. | ||||
| *χ2 p value compares reports of CRC and extracolonic cancer in relatives of CRC cases identified from hospital and population series. | ||||
| †p value compares number of CRC and extracolonic cancer cases between hospital and population series. | ||||
| ‡p value from Fisher’s exact test. | ||||
| ¶p value compares number of family history pedigrees meeting HNPCC criteria between study groups. | ||||
| FDR with CRC | 142 (19.4) | 102 (20.0) | 40 (17.9) | 0.54* |
| No of affected FDRs | ||||
| 0 | 590 (80.6) | 407 (80.0) | 183 (82.1) | |
| 1 | 121 (16.5) | 88 (17.3) | 33 (14.8) | |
| 2 or 3 | 21 (2.9) | 14 (2.7) | 7 (3.1) | 0.39† |
| FDR with extracolonic cancer* | 87 (11.9) | 65 (12.8) | 22 (9.9) | 0.32* |
| No of affected FDRs | ||||
| 0 | 645 (88.1) | 444 (87.2) | 201 (90.1) | |
| 1 | 76 (10.4) | 56 (11.0) | 20 (9.0) | |
| 2 or 3 | 11 (1.5) | 9 (1.8) | 2 (0.9) | 0.63†‡ |
| FH suggestive of HNPCC | ||||
| Total | 19 (2.6) | 14 (2.7) | 5 (2.2) | |
| None | 713 (97.4) | 495 (97.3) | 218 (97.8) | |
| Amsterdam | 6 (0.8) | 6 (1.2) | 0 (0) | |
| Modified | 13 (1.9) | 8 (1.6) | 5 (2.7) | 0.07¶‡ |