Clinical criteria for suspicion of hereditary non-polyposis colorectal cancer (HNPCC).39 Revised ICG-HNPCC criteria (Amsterdam I and II)
| ICG, International Collaborative Group; CRC, colorectal cancer. |
| There should be at least 3 relatives with CRC, or there should be at least 3 relatives with an HNPCC associated cancer (CRC, endometrium, small bowel, ureter, or renal pelvis); all the following should be present: |
| • One should be a first degree relative of the other two |
| • At least 2 successive generations should be affected |
| • At least 1 CRC should be diagnosed before the age of 50 |
| • Familial adenomatous polyposis should be excluded |
| • Tumours should be verified by pathological examination |