Analysis of anti-Saccharomyces cerevisiae antibodies (ASCA) in twins classified with Crohn’s disease (CD) in multivariate categories (stratification for location and behaviour)
| Category | n | Adjusted mean (95% CI) of ASCA (U/ml) | Ratio (95% CI) of ASCA for CD v healthy twin sibling; p value |
|---|---|---|---|
| CD, Crohn’s disease; non-strict non-penetr, non-stricturing non-penetrating; strict/penetr, stricturing or penetrating; HT CD, healthy twin sibling to twin with Crohn’s disease. | |||
| Adjusted mean values of ASCA and ratios of ASCA mean between CD categories and healthy twins (reference category). | |||
| 95% CI, 95% confidence intervals as well as parameter estimates. | |||
| CD, colonic (L2), non-strict non-penetr (B1) | 14 | 4.8 (−2.6–12.2) | 0.9 (0.6–1.5); p = 0.73 |
| CD, colonic (L2), strict/penetr (B2/3) | 7 | 17.1 (8.1–26.2) | 2.2 (1.2–4.1); p = 0.008 |
| CD, small bowel (L1, 3, 4), non-strict non-penetr (B1) | 16 | 16.0 (9.8–22.1) | 2.2 (1.4–3.4); p = 0.004 |
| CD, small Bowel (L1, 3, 4), strict/penetr (B2/3) | 33 | 19.3 (15.0–23.6) | 3.2 (2.4–4.4); p<0.0001 |
| HT CD | 47 | 5.2 (3.2–7.2) | 1.0 (reference) |