Exposure | Controls (n (%)) | Oesophageal adenocarcinoma | Gastric cardia adenocarcinoma | Gastric non-cardia adenocarcinoma | |||
---|---|---|---|---|---|---|---|
(n (%)) | OR (95% CI)* | (n (%)) | OR (95% CI)* | (n (%)) | OR (95% CI)* | ||
*OR adjusted for age, sex, calendar year, smoking, alcohol consumption, body mass index, gastro-oesophageal reflux, hiatal hernia, peptic ulcer, and dyspepsia. | |||||||
†Includes oesophageal ulcer and unspecified peptic ulcer. | |||||||
GOR, gastro-oesophageal reflux; NA, Not applicable. | |||||||
GOR symptoms | |||||||
Never | 9105 (91.0) | 244 (85.0) | 1.00 (reference) | 164 (84.1) | 1.00 (reference) | 292 (89.3) | 1.00 (reference) |
Ever | 895 (9.0) | 43 (15.0) | 1.67 (1.16–2.40) | 31 (15.9) | 1.51 (0.99–2.30) | 35 (10.7) | 1.00 (0.69–1.46) |
Hiatal hernia | |||||||
No | 9490 (94.9) | 256 (89.2) | 1.00 (reference) | 179 (91.8) | 1.00 (reference) | 309 (94.5) | 1.00 (reference) |
Yes | 510 (5.1) | 31 (10.8) | 2.17 (1.44–3.27) | 16 (8.2) | 1.28 (0.75–2.22) | 18 (5.5) | 0.89 (0.54–1.47) |
Peptic ulcer | |||||||
No | 9373 (93.7) | 258 (89.9) | 1.00 (reference) | 171 (87.7) | 1.00 (reference) | 280 (85.6) | 1.00 (reference) |
Gastric ulcer | 157 (1.6) | 7 (2.4) | 1.65 (0.76–3.56) | 7 (3.6) | 2.47 (1.14–5.38) | 16 (4.9) | 3.32 (1.95–5.65) |
Duodenal ulcer | 385 (3.8) | 18 (6.3) | 1.53 (0.93–2.51) | 13 (6.7) | 1.72 (0.96–3.06) | 24 (7.3) | 2.07 (1.34–3.19) |
Gastric + duodenal ulcer | 9 (0.1) | 0 (0.0) | NA | 0 (0.0) | NA | 5 (1.5) | 15.16 (4.97–46.26) |
Other peptic ulcer† | 76 (0.8) | 2 (0.7) | 0.90 (0.22–3.72) | 3 (1.5) | 2.12 (0.66–6.80) | 2 (0.6) | 0.84 (0.20–3.45) |
Dyspepsia | |||||||
Never | 8193 (81.9) | 229 (79.8) | 1.00 (reference) | 136 (69.7) | 1.00 (reference) | 241 (73.7) | 1.00 (reference) |
Ever | 1807 (18.1) | 58 (20.2) | 0.90 (0.66–1.24) | 59 (30.3) | 1.70 (1.22–2.39) | 86 (26.3) | 1.44 (1.10–1.89) |