Table 5

 Distribution of indications for long term use of acid suppressing drugs (proton pump inhibitors or histamine2 receptor antagonists) among cases and controls

IndicationControls (n (%))Oesophageal adenocarcinoma (n (%))Gastric cardia adenocarcinoma (n (%))Gastric non-cardia adenocarcinoma (n (%))
*Including unknown indication, prophylactic indication, or indication of mixed “oesophageal”, “peptic ulcer”, or “gastroduodenal symptom” type.
GORD, gastro-oesophageal reflux disease.
Total343 (100)26 (100)6 (100)20 (100)
GORD57 (17)1 (4)2 (33)3 (15)
Oesophagitis37 (11)4 (15)0 (0)0 (0)
Hiatal hernia28 (8)6 (23)0 (0)2 (10)
Barrett’s3 (1)5 (19)0 (0)0 (0)
All “oesophageal” indications125 (36)16 (62)2 (33)5 (25)
Gastric ulcer9 (3)0 (0)1 (17)3 (15)
Duodenal ulcer31 (9)4 (15)2 (33)5 (25)
Peptic ulcer, unspecified36 (10)2 (8)0 (0)3 (15)
All “peptic ulcer” indications76 (22)6 (23)3 (50)11 (55)
Gastritis20 (6)0 (0)0 (0)1 (5)
Indigestion9 (3)0 (0)0 (0)0 (0)
Dyspepsia63 (18)0 (0)1 (17)2 (10)
Epigastric pain22 (6)2 (8)0 (0)1 (5)
All “gastroduodenal symptom” indications114 (33)2 (8)1 (17)4 (20)
Mixed*28 (8)2 (8)0 (0)0 (0)