Distribution of indications for long term use of acid suppressing drugs (proton pump inhibitors or histamine2 receptor antagonists) among cases and controls
| Indication | Controls (n (%)) | Oesophageal adenocarcinoma (n (%)) | Gastric cardia adenocarcinoma (n (%)) | Gastric non-cardia adenocarcinoma (n (%)) |
|---|---|---|---|---|
| *Including unknown indication, prophylactic indication, or indication of mixed “oesophageal”, “peptic ulcer”, or “gastroduodenal symptom” type. | ||||
| GORD, gastro-oesophageal reflux disease. | ||||
| Total | 343 (100) | 26 (100) | 6 (100) | 20 (100) |
| GORD | 57 (17) | 1 (4) | 2 (33) | 3 (15) |
| Oesophagitis | 37 (11) | 4 (15) | 0 (0) | 0 (0) |
| Hiatal hernia | 28 (8) | 6 (23) | 0 (0) | 2 (10) |
| Barrett’s | 3 (1) | 5 (19) | 0 (0) | 0 (0) |
| All “oesophageal” indications | 125 (36) | 16 (62) | 2 (33) | 5 (25) |
| Gastric ulcer | 9 (3) | 0 (0) | 1 (17) | 3 (15) |
| Duodenal ulcer | 31 (9) | 4 (15) | 2 (33) | 5 (25) |
| Peptic ulcer, unspecified | 36 (10) | 2 (8) | 0 (0) | 3 (15) |
| All “peptic ulcer” indications | 76 (22) | 6 (23) | 3 (50) | 11 (55) |
| Gastritis | 20 (6) | 0 (0) | 0 (0) | 1 (5) |
| Indigestion | 9 (3) | 0 (0) | 0 (0) | 0 (0) |
| Dyspepsia | 63 (18) | 0 (0) | 1 (17) | 2 (10) |
| Epigastric pain | 22 (6) | 2 (8) | 0 (0) | 1 (5) |
| All “gastroduodenal symptom” indications | 114 (33) | 2 (8) | 1 (17) | 4 (20) |
| Mixed* | 28 (8) | 2 (8) | 0 (0) | 0 (0) |