Exposure | Controls (n (%)) | Oesophageal adenocarcinoma | |
---|---|---|---|
(n (%)) | OR (95% CI)¶ | ||
*More than 3 years of current use of either proton pump inhibitors (PPI) or histamine2 receptor antagonists (H2 blockers). | |||
†Including gastro-oesophageal reflux, oesophagitis, hiatal hernia, or Barrett’s oesophagus. | |||
‡Including gastric ulcer, duodenal ulcer and unspecified peptic ulcer, gastritis, dyspepsia, indigestion, epigastric pain, unknown indication, prophylactic indication, or indication of mixed type. | |||
¶All ORs adjusted for age, sex, calendar year, smoking, alcohol consumption, and body mass index. | |||
Indication for long term use of PPI or H2 blockers* | |||
“Oesophageal”† | 125 (1.2) | 16 (5.6) | 5.42 (3.13–9.39) |
Other indications ‡ | 218 (2.2) | 10 (3.5) | 1.74 (0.90–3.34) |