Exposure | Controls (n (%)) | Gastric cardia adenocarcinoma | Gastric non-cardia | ||
---|---|---|---|---|---|
(n (%)) | OR (95% CI)¶ | (n (%)) | OR (95% CI)¶ | ||
*More than 3 years of current use of either proton pump inhibitors (PPI) or histamine2 receptor antagonists (H2 blockers). | |||||
†Including gastric ulcer, duodenal ulcer, and unspecified peptic ulcer. | |||||
‡Including gastro-oesophageal reflux, oesophagitis, hiatal hernia, Barrett’s oesophagus, gastritis, dyspepsia, indigestion, epigastric pain, unknown indication, prophylactic indication, or indication of mixed type. | |||||
¶All ORs adjusted for age, sex, calendar year, smoking, alcohol consumption, and body mass index. | |||||
Indication for long term use of PPI or H2 blockers* | |||||
“Peptic ulcer”† | 76 (0.8) | 3 (1.5) | 2.18 (0.67–7.03) | 11 (3.4) | 4.66 (2.42–8.97) |
Other indication‡ | 267 (2.7) | 3 (1.5) | 0.68 (0.21–2.14) | 9 (2.8) | 1.18 (0.60–2.32) |