Table 1

Histological criteria for grading dysplasia in Barrett’s oesophagus

	Criteria
Adapted from Geboes and Van Eyken,³⁰ Riddell et al,³¹ Montgomery et al.³⁷
Negative for dysplasia	Architecture within normal limits. No nuclear abnormalities, except focal nuclear stratification. Greater nuclear alterations acceptable when associated with inflammation, erosion, or ulceration.
Indefinite	Architecture may be moderately distorted. Nuclear abnormalities less marked than those seen in dysplasia. Changes too marked for negative but not sufficient for the diagnosis of dysplasia.
Positive for dysplasia	Architectural and cytological changes severe enough to suggest neoplastic transformation. Diagnosis of high grade or low grade based on the severity of changes: high grade dyspasia is diagnosed if either architectural and/or cytological abnormalities are sufficiently prominent. Alterations are especially noteworthy if they involve the mucosal surface.
Intramucosal carcinoma	Carcinoma has penetrated through the basement membrane of the glands into the lamina propria but not yet invaded the submucosa.