Characteristics of initial oesophageal biopsies
| Biopsy characteristic | No of cases* (%) | No of controls (%) |
|---|---|---|
| *Incident oesophageal malignancy and high grade dysplasia. | ||
| COX-2, cyclooxygenase 2. | ||
| Dysplasia | ||
| None or indefinite | 33 (97.1) | 161 (98.8) |
| Low grade | 0 | 2 (1.2) |
| High grade | 1 (2.9) | 0 |
| Inflammation | ||
| None or mild (0, 1) | 25 (73.5) | 106 (65.0) |
| Moderate or severe (2, 3) | 9 (26.5) | 57 (35.0) |
| Cyclin D1 staining | ||
| Grade 0 (none) | 5 (14.7) | 29 (17.8) |
| Grade 1 (focal) | 19 (55.9) | 70 (42.9) |
| Grade 2 (diffuse) | 8 (23.5) | 52 (31.9) |
| Grade 3 (intense) | 2 (5.9) | 12 (7.4) |
| TP53 staining | ||
| Grade 0 (none) | 13 (38.2) | 85 (52.1) |
| Grade 1 (focal) | 10 (29.4) | 59 (36.2) |
| Grade 2 (diffuse) | 8 (23.5) | 17 (10.4) |
| Grade 3 (intense) | 3 (8.8) | 2 (1.2) |
| COX-2 staining | ||
| Grade 0 | 7 (20.6) | 28 (17.3) |
| Grade 1 | 18 (52.9) | 106 (65.4) |
| Grade 2 | 8 (23.5) | 28 (17.3) |
| Grade 3 | 1 (2.9) | 0 |
| β-catenin staining | ||
| Grade 0 (none) | 21 (63.6) | 105 (65.2) |
| Grade 1 (focal) | 11 (33.3) | 54 (33.5) |
| Grade 2 (diffuse) | 1 (3.0) | 2 (1.2) |
| Grade 3 (intense) | 0 | 0 |