Table 3

 Effects of intravenous exendin(9-39)NH2 on antro-pyloro-duodenal motility during duodenal glucose perfusion at different rates

IV infusionDuodenal glucose perfusion rate (60 min each)
1 kcal/min2.5 kcal/min2.5 kcal/min (recovery)
Saline ivEx(9-39)Saline ivEx(9-39)Saline ivSaline iv
IPPW, isolated pyloric pressure waves; iv, intravenous.
Mean (SEM) of actual values and of values over basal (pyloric tone) during each 60 minute perfusion period. Values for pressure waves and motility indices represent the sum of two antral and three duodenal side holes, respectively (n = 9).
Differences were compared using two way repeated measures ANOVA employing individual incremental or decremental values during the respective periods.
*p<0.05 versus saline iv.
Antral motility
    Pressure waves (No/60 min)13 (3.3)46 (7.5)*8.0 (2.6)16 (3.7)*24 (6.3)20 (4.7)
    Motility index (mm Hg×s/60 min)4498 (1622)9954 (2645)*364 (144)1016 (250)*1549 (461)2372 (901)
    Amplitude (mm Hg)49 (11)49 (6.9)21 (4.0)25 (6.2)31 (6.8)37 (7.7)
Duodenal motility
    Pressure waves (No/60 min)141 (10)195 (17)*74 (12)151 (11)*131 (20)143 (17)
    Motility index (mmHg×s/60 min)7118 (1278)9785 (1376)*3463 (612)5711 (804)*5416 (982)5776 (877)
Amplitude (mm Hg)23 (0.8)24 (1.5)21 (2.0)22 (1.7)22 (1.9)24 (1.2)
Pyloric motility
    IPPW (No/60 min)26 (5.5)14 (2.7)53 (9.5)24 (6.2)*47 (9.2)28 (8.1)*
    Pyloric tone (mm Hg)6.2 (1.0)5.0 (0.8)9.8 (1.3)5.8 (1.1)*11 (1.5)6.3 (1.3)*