Table 2

 Intragastric pH in mice with either a sham operation or oesophagitis

GenotypeOperationDrugIntragastric pH
VR-1, vanilloid receptor subtype 1.
A subset of mice were administered famotidine, omeprazole, or capsazepine. Note that sham operated mice did not have a significant reduction in intragastric pH, while both (+/+) and (−/−) mice with oesophagitis had a significant reduction in pH. Note the increase in pH levels following antisecretory and VR-1 antagonism therapy.
Values are mean (SD).
**p<0.01 compared with VR-1 (+/+).
VR-1 (+/+)Sham6.12 (0.89)
VR-1 (−/−)Sham5.98 (0.95)
VR-1 (+/+)Oesophagitis2.15 (0.43)
VR-1 (−/−)Oesophagitis2.28 (0.33)
VR-1 (+/+)OesophagitisFamotidine4.23 (1.53)**
VR-1 (+/+)OesophagitisOmeprazole5.81 (0.35)**
VR-1 (+/+)OesophagitisCapsazepine4.33 (0.80)**