Direct effects of dexamethasone or antibiotics on visceral sensitivity
| Before intrarectal administration | After intrarectal administration | |
|---|---|---|
| *p = 0.03 versus before intrarectal administration. Mice (n = 12/group) were distended three times before and three times after administration of active substances. | ||
| Data are median (IQR) of three distensions expressed as percentage of change versus the first distension (1st distension = 100%). | ||
| Saline | 102% (80–145) | 97% (70–110) |
| Histamine | 100% (99–110) | 152% (130–250)* |
| Dexamethasone | 100% (79–108) | 95% (67–99) |
| Antibiotic combination | 100% (88–115) | 100% (60–115) |