Univariate and multivariate analysis of the cytokine loci between patients with perforated duodenal ulcer (n = 29) and all blood donors (n = 539), and between patients with perforated duodenal ulcer (n = 29) and Helicobacter pylori positive blood donors (n = 369)
| Genotype | All subjects | H pylori positive subjects | |||||
|---|---|---|---|---|---|---|---|
| Uni | Multivariate | Uni | Multivariate | ||||
| p Value | OR | 95% CI | p Value | OR | 95% CI | ||
| Uni, univariate; OR, odds ratio; 95% CI, 95% Cornfield confidence intervals; Ref, reference (wild) genotype; IL, interleukin; TNF, tumour necrosis factor. | |||||||
| cagA positive status | 1/1 | 0.00 | 24.72 | 3.29–185.66 | |||
| IL-1B−31 | T/T | Ref | Ref. | ||||
| C carrier | 0.04 | 0.42 | 0.20–0.90 | 0.05 | 0.33 | 0.15–0.73 | |
| IL-1RN | 1/1 | Ref | Ref. | ||||
| 2 carrier | 0.60 | 0.70 | |||||
| TNFA−307 | G/G | Ref | Ref. | ||||
| A carrier | 0.03 | 0.21 | 0.05–0.88 | 0.03 | 0.21 | 0.05–0.96 | |