Table 1

 Univariate and multivariate analysis of the cytokine loci between patients with perforated duodenal ulcer (n = 29) and all blood donors (n = 539), and between patients with perforated duodenal ulcer (n = 29) and Helicobacter pylori positive blood donors (n = 369)

GenotypeAll subjectsH pylori positive subjects
UniMultivariateUniMultivariate
p ValueOR95% CIp ValueOR95% CI
Uni, univariate; OR, odds ratio; 95% CI, 95% Cornfield confidence intervals; Ref, reference (wild) genotype; IL, interleukin; TNF, tumour necrosis factor.
cagA positive status1/10.0024.723.29–185.66
IL-1B−31T/TRefRef.
C carrier0.040.420.20–0.900.050.330.15–0.73
IL-1RN 1/1RefRef.
2 carrier0.600.70
TNFA−307G/GRefRef.
A carrier0.030.210.05–0.880.030.210.05–0.96