Table 6

 Rate of advent of complications from diagnosis of primary biliary cirrhosis (PBC) to the last follow up in 43 patients with PBC-systemic sclerosis (PBC-SSc) and 82 with PBC alone, matched by serum bilirubin at referral to Royal Free Hospital

Complication‡PBC-SSc (n = 43)PBC (n = 82)
Values are number (%).
*p = 0.03 (Pearson χ2 test), 95% confidence interval (CI) 1.48–4.09.
†p = 0.005 (Pearson χ2 test), 95% CI 2.39–4.02.
‡Log rank test was done for comparison of time to occurrence of complications. No significant differences were observed.
New pruritus7 (16%)7 (9%)
New fatigue13 (30%)23 (28%)
Ankle oedema15 (35%)22 (27%)
Ascites11 (26%)21 (26%)
Oesophageal varices13 (30%)28 (34%)
Variceal bleeding8 (19%)13 (16%)
Upper gastrointestinal non-variceal bleeding5 (12%)4 (5%)
Spontaneous bacterial peritonitis4 (9%)*1 (1%)*
Portosystemic encephalopathy5 (12%)7 (9%)
Hepatocellular carcinoma0 (0%)2 (2%)
Septicaemia4 (9%)†0 (0%)†