Table 1

 Clinical feature of mucosa associated lymphoid tissue (MALT) lymphoma with t(1;14)(p22;q32) or variants

Case NoAgeSexPrimary siteGenetic investigationsBCL10 involved chromosomal translocationBCL10 IHCStaging*DisseminationClinical follow up
*Ann Arbor-Musshoff staging system for extranodal lymphoma; the clinical stage was likely to have been underestimated as appropriate staging was unlikely to be carried out in each of these archival cases.
IHC, immunohistochemistry; FISH, fluorescence in situ hybridisation; n/a, not available.
1871MStomachKarotyping, interphase FISH, molecular cloningt(1;14)(p22;q32)Strong nuclear stainingIVEPerigastric lymph nodes, omentum, spleen, pleural effusion, bloodn/a
248FStomachKarotyping, interphase FISHt(1;14)(p22;q32)n/aIVEPerigastric and splenic hilus lymph nodes, pleural involvement, bone marrow involvement?4 cycles of MCP chemotherapy, partial remission, alive at two year follow up
367MStomachKarotyping, interphase FISHt(1;2)(p22;q12)Strong nuclear stainingIIIEPerigastric lymph nodes and spleenChemotherapy with chlorambucil, complete remission in three year follow up
473FStomachInterphase FISHYesStrong nuclear stainingIIIEPerigastric and mesenteric lymph nodes,Low dose chlorambucil chemotherapy, complete remission at 1.5 year follow up
549MStomachInterphase FISHYesStrong nuclear stainingIVELungn/a
6n/an/aStomachKarotyping, interphase FISHt(1;14)(p22;q32)Strong nuclear stainingIIEn/an/a
7963FLungKarotyping, interphase FISHt(1;14)(p22;q32)n/aIVEBlood, bilateral pulmonary involvement, pleural and ascitic effusions, retroperitoneal lymph node8 year low grade B cell lymphoma, then presented an aggressive clinical course presenting with lymphocytosis, pleural and ascitic effusions, partially response to chemotherapy, died of disease
8949FLungKarotyping, interphase FISHt(1;14)(p22;q32)n/aIIEn/an/a
957FLungInterphase FISHIGH-BCL10 fusionStrong BCL10 nuclear stainingIENo clinical evidenceData on treatment not available, but patients alive without evidence of disease for 16 years
1032FBreastKarotyping, interphase FISHt(1;14)(p22;q32)n/aIIEAxillary lymph nodes6 cycles of CHOP therapy followed by surgery, complete remission in two year follow up
1175FBreastInterphase FISHIGH-BCL10 fusionStrong BCL10 nuclear stainingIENo clinical evidencen/a