Clinical feature of mucosa associated lymphoid tissue (MALT) lymphoma with t(1;14)(p22;q32) or variants
| Case No | Age | Sex | Primary site | Genetic investigations | BCL10 involved chromosomal translocation | BCL10 IHC | Staging* | Dissemination | Clinical follow up |
|---|---|---|---|---|---|---|---|---|---|
| *Ann Arbor-Musshoff staging system for extranodal lymphoma; the clinical stage was likely to have been underestimated as appropriate staging was unlikely to be carried out in each of these archival cases. | |||||||||
| IHC, immunohistochemistry; FISH, fluorescence in situ hybridisation; n/a, not available. | |||||||||
| 18 | 71 | M | Stomach | Karotyping, interphase FISH, molecular cloning | t(1;14)(p22;q32) | Strong nuclear staining | IVE | Perigastric lymph nodes, omentum, spleen, pleural effusion, blood | n/a |
| 2 | 48 | F | Stomach | Karotyping, interphase FISH | t(1;14)(p22;q32) | n/a | IVE | Perigastric and splenic hilus lymph nodes, pleural involvement, bone marrow involvement? | 4 cycles of MCP chemotherapy, partial remission, alive at two year follow up |
| 3 | 67 | M | Stomach | Karotyping, interphase FISH | t(1;2)(p22;q12) | Strong nuclear staining | IIIE | Perigastric lymph nodes and spleen | Chemotherapy with chlorambucil, complete remission in three year follow up |
| 4 | 73 | F | Stomach | Interphase FISH | Yes | Strong nuclear staining | IIIE | Perigastric and mesenteric lymph nodes, | Low dose chlorambucil chemotherapy, complete remission at 1.5 year follow up |
| 5 | 49 | M | Stomach | Interphase FISH | Yes | Strong nuclear staining | IVE | Lung | n/a |
| 6 | n/a | n/a | Stomach | Karotyping, interphase FISH | t(1;14)(p22;q32) | Strong nuclear staining | IIE | n/a | n/a |
| 79 | 63 | F | Lung | Karotyping, interphase FISH | t(1;14)(p22;q32) | n/a | IVE | Blood, bilateral pulmonary involvement, pleural and ascitic effusions, retroperitoneal lymph node | 8 year low grade B cell lymphoma, then presented an aggressive clinical course presenting with lymphocytosis, pleural and ascitic effusions, partially response to chemotherapy, died of disease |
| 89 | 49 | F | Lung | Karotyping, interphase FISH | t(1;14)(p22;q32) | n/a | IIE | n/a | n/a |
| 9 | 57 | F | Lung | Interphase FISH | IGH-BCL10 fusion | Strong BCL10 nuclear staining | IE | No clinical evidence | Data on treatment not available, but patients alive without evidence of disease for 16 years |
| 10 | 32 | F | Breast | Karotyping, interphase FISH | t(1;14)(p22;q32) | n/a | IIE | Axillary lymph nodes | 6 cycles of CHOP therapy followed by surgery, complete remission in two year follow up |
| 11 | 75 | F | Breast | Interphase FISH | IGH-BCL10 fusion | Strong BCL10 nuclear staining | IE | No clinical evidence | n/a |