Cancer diagnosis in first-degree relatives
| Characteristics | Number | Age (years) |
|---|---|---|
| BLC, bladder cancer; BTC, biliary tract cancer; CRC, colorectal cancer; EC, endometrial cancer; FD, first-degree; GIC, gastrointestinal cancer; HNPCC, hereditary non-polyposis colorectal cancer; OC, ovarian cancer; PC, pancreatic cancer; RPC, renal pelvic cancer; STC, stomach cancer; UC, ureteric cancer. | ||
| *Some parents had multiple HNPCC-associated tumours. | ||
| †Five patients had a parent with CRC and parent with an HNPCC-associated cancer. | ||
| Patients with FD relative with HNPCC-associated cancer | 111 | |
| Mean age (SD, range) at diagnosis of first cancer of index patient | 47 (11, 13–77) | |
| Number of affected parents* | 88 parents | |
| (2× both parents)† | ||
| CRC | 49 | |
| EC | 12 | |
| STC | 12 | |
| GIC | 4 | |
| PC | 2 | |
| RPC, UC, BLC | 10 | |
| BTC | 3 | |
| OC | 3 | |
| Siblings with CRC | 28 (including 1 half-sibling) | |
| Siblings with HNPCC-associated cancer other than CRC | 14 (including 1 half-sibling) | |
| Children with CRC | 3 | |
| Children with HNPCC-associated cancer other than CRC | 1 | |
| Patients without an FD relative with HNPCC-associated cancer | 170 | |
| Mean age (SD, range) at diagnosis of first cancer of index patient | 45 (10, 19–75) | |