Table 2

 Amino acid substitutions resulting in antagonists (p<0.02)

SubstitutionAntagonism (%) [p value]Agonism (%)SubstitutionAntagonism (%) [p value]Agonism (%)
Values are mean (SEM).
*Significant at p<0.02 after Bonferroni correction for multiple comparisons (131).
†Antagonism significant (p⩽0.005) when assessed in a second sample of 10 CD subjects with coeliac disease (CD).
‡Antagonism not significant (p>0.05) when assessed in a second sample of 10 CD subjects.
63Q→W14 (3) [0.001]38 (7)67P→A14 (5) [0.01]29 (5)
64P→F14 (4) [0.006]8 (4)67P→D18 (4) [0.001]25 (10)
64P→G15 (5) [0.01]18 (4)67P→G12 (3) [0.002]13 (3)
64P→R18 (5) [0.002]18 (14)67P→H14 (5) [0.01]15 (6)
64P→S16 (3) [0.0004]32 (7)67P→I‡24 (6) [0.001]24 (7)
64P→T*28 (4) [0.0001]47 (6)67P→K14 (6) [0.02]3 (2)
64P→W†21 (6) [0.004]10 (6)67P→V*24 (4) [0.0001]30 (7)
64P→Y†17 (7) [0.01]29 (11)68Y→E15 (6) [0.02]33 (5)
65E→H†18 (6) [0.01]40 (6)68Y→L12 (4) [0.004]43 (5)
65E→I‡20 (5) [0.001]19 (5)68Y→S16 (5) [0.004]58 (9)
65E→Q13 (5) [0.02]12 (2)69P→G13 (5) [0.01]50 (6)
65E→R‡16 (6) [0.02]7 (6)69P→I‡10 (4) [0.01]57 (22)
65E→S15 (3) [0.001]48 (5)69P→L17 (7) [0.02]31 (3)
65E→T*†28 (5) [0.0001]3 (5)69P→N14 (6) [0.02]46 (10)
65E→W17 (6) [0.01]8 (4)69P→Q12 (4) [0.01]35 (5)
66L→G11 (4) [0.01]6 (4)