Table 2

 Prevalence of CARD15 mutations

GenotypeControlCDCD-RCD-NR
CD, Crohn’s disease; CD-R, first degree relative of a patient with CD; CD-NR, non-related household member living with a patient with CD.
Overall, number of persons carrying at least one mutation.
p values for differences in frequency distribution of CARD15 mutations between CD groups and controls (Fisher’s exact test)
Number of cases in parentheses.
3020insC(n = 62)(n = 121)(n = 106)(n = 50)
    Wild-type98% (61)78% (94)77% (82)88% (44)
    Heterozygous mutant2% (1)18% (22)22% (23)10% (5)
    Homozygous mutant4% (5)1% (1)2% (1)
p<0.0005p<0.0005p = 0.044
R702W(n = 62)(n = 120)(n = 106)(n = 50)
    Wild-type94% (58)83% (100)84% (89)88% (44)
    Heterozygous mutant6% (4)14% (17)15% (16)12% (6)
    Homozygous mutant3% (3)1% (1)
p = 0.06p = 0.091p = 0.337
G908R(n = 62)(n = 120)(n = 105)(n = 50)
    Wild-type97% (60)92% (110)98% (103)98% (49)
    Heterozygous mutant3% (2)8% (10)2% (2)2% (1)
p = 0.343p = 0.628p = 1.000
Overall(n = 62)(n = 121)(n = 106)(n = 50)
11% (7)43% (52)37% (39)24% (12)