Clinical and biochemical parameters among patients with acute liver failure (n = 80)
| Parameter | |
|---|---|
| Quantitative data are given as median (range). | |
| pNH3, partial pressure of ammonia; data for 71 patients. | |
| *Markers of acute hepatitis A, B, and/or E viral infection—71.8% of patients; isolated hepatitis B surface antigen or anti-hepatitis C virus antibody—9.9% of patients; acute hepatitis E infection, either alone or as dual infection—53.5% of cases. | |
| Age (y) | 25.0 (14–72) |
| Encephalopathy grades 3, 4 (No (%)) | 58 (72.5) |
| Cerebral oedema (No (%)) | 28 (35.0) |
| Pre-encephalopathy interval (days) | 6.0 (2–29) |
| Icterus encephalopathy interval (days) | 3.0 (0–28) |
| Bilirubin (mg/dl) | 14.1 (3.9–42.0) |
| Alanine aminotransferase (IU/l) | 1115.0 (122.0–7206.0) |
| Albumin (mg/dl) | 2.7 (1.6–4.5) |
| Prothrombin time increase (s) | 28.5 (4–48) |
| Urea (mg/dl) | 16.0 (14–90) |
| Sex (females) (No (%)) | 51 (63.8) |
| Pregnancy (No (%)) | 20 (39.2) |
| Ammonia (μmol/l) | 128.6 (9.3–735.0) |
| pNH3 (×10−5 mm Hg) | 6.28 (0.26–41.06) |
| Lactate (mmol/l) | 4.6 (1.2–31.0) |
| Bicarbonate (mEq/l) | 20.0 (5.9–32.2) |
| Sodium (mEq/l) | 138.5 (122.0–161.0) |
| Blood pH | 7.49 (7.02–7.80) |
| Admission to death (days) | 4.0 (1–17) |
| Awake time (days) | 4.0 (1–12) |
| Aetiology | |
| Post viral* | 81.7% |
| ATT induced | 5.6% |
| No evident cause | 12.7% |