Table A1

 Sensitivity and specificity of each methylation marker for overall CpG island methylator phenotype (CIMP) status

MarkerTotal NoCIMP (six markers)CIMP (five markers. No MGMT)
Positive (⩾4/6)Negative (⩽3/6)Positive (⩾4/5)Negative (⩽3/5)
*Prevalence of CIMP.
†Sensitivity defined by “(the number of CIMP cases positive for a given marker)/(the number of all CIMP positive cases)”.
‡Specificity defined by “(the number of non-CIMP (CIMP negative) cases negative for a given marker)/(the number of all non-CIMP cases)”.
Total No46094 (20%)*36678 (17%)*382
CACNA1GPositive10884 (89%)†2476 (97%)†32
Negative35210342 (93%)‡2350 (92%)‡
CDKN2APositive14783 (88%)†6471 (91%)†75
Negative31311302 (83%)‡7307 (80%)‡
CRABP1Positive16493 (99%)†7178 (100%)†86
Negative2961295 (81%)‡0296 (77%)‡
MGMTPositive18358 (62%)†125
Negative27736241 (66%)‡
MLH1Positive7060 (64%)†1058 (74%)†12
Negative39034356 (97%)‡20370 (97%)‡
NEUROG1Positive15588 (94%)†6777 (99%)†78
Negative3056299 (82%)‡1304 (80%)‡