Table 2

 Sex and frequency of CpG island methylator phenotype (CIMP)

CohortNo of methylated lociCIMP
012345⩾4
Cases of men were derived from the Health Professional Follow up Study (n = 51 500 men) and cases of women were from the Nurses’ Health Study (n = 121 700 women).
*Men versus women, p = 0.02.
Men7740221371320/172 (12%)*
Women136463018223658/288 (20%)*