Table 4

KRAS and BRAF mutations, and frequency of CpG island methylator phenotype (CIMP)

KRASBRAFNo of methylated lociCIMP
012345⩾4
*KRAS mutant versus BRAF mutant, p = 10−20; †KRAS mutant versus both wild-types, p = 0.05; ‡BRAF mutant versus both wild-types, p = 6×10−17.
MutantWild-type59372110527/134 (5.2%)*†
Wild-typeMutant5267142943/63 (68%)*‡
Wild-typeWild-type1073417881523/189 (12%)†‡