Microsatellite instability, KRAS and BRAF status, and frequency of CpG island methylator phenotype (CIMP)
| MSI status | KRAS | BRAF | No of methylated loci | CIMP | |||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5 | ⩾4 | |||
| MSI-H, microsatellite instability-high; MSI-L, microsatellite instability-low; MSS, microsatellite stable. | |||||||||
| *KRAS mutant versus BRAF mutant, p = 2×10−6; †KRAS mutant versus both wild-types, p = 0.03; ‡BRAF mutant versus both wild-types, p = 0.0002; §KRAS mutant versus BRAF mutant, p = 0.0005; ¶BRAF mutant versus both wild-types, p = 2×10−5. | |||||||||
| MSI-H | Mutant | Wild-type | 3 | 2 | 1 | 0 | 0 | 1 | 1/7 (14%)*† |
| Wild-type | Mutant | 0 | 0 | 0 | 0 | 7 | 27 | 34/34 (100%)*‡ | |
| Wild-type | Wild-type | 7 | 2 | 1 | 0 | 4 | 15 | 19/29 (66%)†‡ | |
| MSS | Mutant | Wild-type | 49 | 32 | 18 | 9 | 4 | 0 | 4/112 (3.6%)§ |
| Wild-type | Mutant | 5 | 1 | 6 | 5 | 7 | 0 | 7/24 (29%)§¶ | |
| Wild-type | Wild-type | 85 | 28 | 15 | 5 | 2 | 0 | 2/135 (1.5%)¶ | |