Table 5

 Microsatellite instability, KRAS and BRAF status, and frequency of CpG island methylator phenotype (CIMP)

MSI statusKRASBRAFNo of methylated lociCIMP
012345⩾4
MSI-H, microsatellite instability-high; MSI-L, microsatellite instability-low; MSS, microsatellite stable.
*KRAS mutant versus BRAF mutant, p = 2×10−6; †KRAS mutant versus both wild-types, p = 0.03; ‡BRAF mutant versus both wild-types, p = 0.0002; §KRAS mutant versus BRAF mutant, p = 0.0005; ¶BRAF mutant versus both wild-types, p = 2×10−5.
MSI-HMutantWild-type3210011/7 (14%)*†
Wild-typeMutant000072734/34 (100%)*‡
Wild-typeWild-type721041519/29 (66%)†‡
MSSMutantWild-type4932189404/112 (3.6%)§
Wild-typeMutant5165707/24 (29%)§¶
Wild-typeWild-type8528155202/135 (1.5%)¶