Cancer risk differences in Peutz-Jeghers syndrome patients between missense (M) versus truncating (T) mutation carriers
| Sex | No of cancers of each type (% of subgroup) by mutation type (M or T) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| All cancers | Gastrointestinal | Gynaecological | Breast | Other | |||||||
| M | T | M | T | M | T | M | T | M | T | ||
| NE, not estimable. | |||||||||||
| Overall | 20 (21%) | 4 (14%) | 15 (15%) | 3 (10%) | – | – | – | – | 2 (2%) | 0 (0%) | |
| p = 0.45 | p = 0.40 | – | – | p = 0.73 | |||||||
| Males | 9 (18%) | 2 (14%) | 8 (16%) | 2 (14%) | – | – | – | – | 1 (2%) | 0 (0%) | |
| p = 0.66 | p = 0.50 | – | – | p = 0.62 | |||||||
| Females | 11 (24%) | 2 (13%) | 7 (15%) | 1 (7%) | 5 (11%) | 1 (7%) | 1 (2%) | 0 (0%) | 1 (2%) | 0 (0%) | |
| p = 0.57 | p = 0.61 | p = 0.74 | p = 0.72 | NE | |||||||