Improvement in each disease activity index (DAI) assessment parameter in the two week double blind study (No of patients (%))
| High trough group | Low trough group | Placebo | |||
|---|---|---|---|---|---|
| p Value: Dunnett-type multiple comparison of difference in DAI score between end of treatment and baseline was used to compare each of the tacrolimus groups (high trough or low trough group) and placebo group. | |||||
| n = 60 | |||||
| Bowel movement | 17/19 (89.5) | (p = 0.001) | 15/21 (71.4) | (p = 0.031) | 8/20 (40.0) |
| Blood in stool | 16/19 (84.2) | (p = 0.001) | 15/21 (71.4) | (p = 0.015) | 8/20 (40.0) |
| Endoscopic findings | 16/19 (84.2) | (p = 0.002) | 10/20 (50.0) | (p = 0.154) | 4/17 (23.5) |
| Physician’s global impression | 16/19 (84.2) | (p = 0.010) | 14/20 (70.0) | (p = 0.050) | 6/17(35.3) |