Table 2

 Effect of carbon tetrachloride (CCl4) and pioglitazone (PGZ) treatment on body weight, liver weight, and spleen weight

ControlCCl4 2 wkCCl4 5 wkCCl4 2 wk + CCl4/PGZ 3 wkCCl4 9 wkCCl4 5 wk + CCl4/PGZ 4 wk
*p<0.05 or higher degree of significance versus controls.
†p<0.05 or higher degree of significance versus CCl4 2 wk.
‡p<0.05 or higher degree of significance versus CCl4 5 wk.
Body weight (g)287 (35)314 (47)356 (26)366 (39)439 (21)397 (41)
Liver (g)11.3 (1.3)13.0 (1.4)14.3 (2.1)15.6 (1.5)15.5 (2.4)12.4 (4.0)
Liver to body weight ratio3.93 (0.25)4.18 (0.47)4.01 (0.45)4.3 (0.71)3.53 (0.47)3.07 (0.75)
Spleen (g)0.83 (0.04)0.97 (0.14)*1.37 (0.10)*,†1.15 (0.12)*,†,‡1.87 (0.06)*,†,‡1.9 (0.410)*,†,‡