Table 1

 Baseline clinical data

VariablePlacebo (n = 8)BQ-123 (n = 8)BQ-788 (n = 8)
Values are expressed as mean (SD).
ET, endothelin.
*Normal range 20−60 pg/ml.
†Normal range 0.5−5 pg/ml.
Age (y) (mean (SD))50 (4)54 (7)52 (9)
Sex (M/F)8/07/18/0
Body mass index (kg/m2)23 (3)24 (2)25 (3)
Child-Pugh score6 (2)6 (2)6 (1)
Child-Pugh grade (A/B)5/34/45/3
Ascites present221
Varices878
Bilirubin (μmol/l)29 (16)30 (17)27 (24)
Albumin (g/l)38 (6)38 (8)41 (7)
Prothrombin time (s)12 (2)11 (3)11 (2)
Big ET-1 (pg/ml)*79 (30)68 (24)60 (15) (n = 7)
ET-1 (pg/ml)†8 (3)7 (2)7 (1) (n = 7)
Aetiology
    Alcoholic656
    Hepatitis C232