Variable | Placebo (n = 8) | BQ-123 (n = 8) | BQ-788 (n = 8) |
---|---|---|---|
Values are expressed as mean (SD). | |||
ET, endothelin. | |||
*Normal range 20−60 pg/ml. | |||
†Normal range 0.5−5 pg/ml. | |||
Age (y) (mean (SD)) | 50 (4) | 54 (7) | 52 (9) |
Sex (M/F) | 8/0 | 7/1 | 8/0 |
Body mass index (kg/m2) | 23 (3) | 24 (2) | 25 (3) |
Child-Pugh score | 6 (2) | 6 (2) | 6 (1) |
Child-Pugh grade (A/B) | 5/3 | 4/4 | 5/3 |
Ascites present | 2 | 2 | 1 |
Varices | 8 | 7 | 8 |
Bilirubin (μmol/l) | 29 (16) | 30 (17) | 27 (24) |
Albumin (g/l) | 38 (6) | 38 (8) | 41 (7) |
Prothrombin time (s) | 12 (2) | 11 (3) | 11 (2) |
Big ET-1 (pg/ml)* | 79 (30) | 68 (24) | 60 (15) (n = 7) |
ET-1 (pg/ml)† | 8 (3) | 7 (2) | 7 (1) (n = 7) |
Aetiology | |||
Alcoholic | 6 | 5 | 6 |
Hepatitis C | 2 | 3 | 2 |