Baseline haemodynamic variables
| Variable | Placebo (n = 8) | BQ-123 (n = 8) | BQ-788 (n = 8) |
|---|---|---|---|
| Values are expressed as mean (SD). | |||
| HR, heart rate; MAP, mean arterial pressure; CI, cardiac index; SVRI, systemic vascular resistance index; WHVP, wedged hepatic venous pressure; FHVP, free hepatic venous pressure; HVPG, hepatic venous pressure gradient; HBF, hepatic blood flow; ICG, indocyanine green; PAWP, pulmonary artery wedge pressure; RAP, right atrial pressure; MPAP, mean pulmonary artery pressure; PVRI, pulmonary vascular resistance index. | |||
| *p<0.05 compared with placebo. | |||
| †Normal range 400−600 ml/min.23 | |||
| n = 8 unless otherwise stated. | |||
| Systemic haemodynamics | |||
| HR (beats/min) | 85 (20) | 76 (9) | 77 (17) |
| MAP (mmHg) | 87 (17) | 86 (11) | 87 (10) |
| CI (l/min/m2) | 4 (1) | 5 (3) | 4 (2) |
| SVRI (dyn×s×m2/cm5) | 1960 (1046) | 1935 (1141) | 2148 (949) |
| Portal haemodynamics | |||
| WHVP (mm Hg) | 24 (4) | 22 (6) | 18 (4)* |
| FHVP (mm Hg) | 5 (4) | 6 (2) | 5 (4) |
| HVPG (mm Hg) | 19 (5) | 16 (6) | 13 (4) |
| HBF (ml/min)† | 853 (397) (n = 4) | 922 (925) (n = 6) | 701 (283) (n = 7) |
| ICG hepatic concentration (mg/ml) | 2 (1.5) | 8 (17) | 5 (10) |
| ICG peripheral concentration (mg/ml) | 4 (1.4) | 10 (16) | 5 (3) |
| Pulmonary haemodynamics | |||
| PAWP (mm Hg) | 4 (2) | 5 (5) | 5 (3) |
| RAP (mm Hg) | 3 (2) | 5 (3) | 3 (4) |
| MPAP (mm Hg) | 9 (2) | 10 (5) | 10 (4) |
| PVRI (dyn×s×m2/cm5) | 134 (87) | 135 (98) | 150 (104) |