Table 1

 Symptom severity before the run in period and before each treatment period

Visit 0 (before run in)Visit 1 (before 1st treatment period)Visit 4 (before 2nd treatment period)
*Significantly different from visit 1 (p<0.05).
Overall severity assessment7.5 (0.3)7.5 (0.3)6.2 (0.6)*
No of days with impact on daily life5.0 (0.2)5.0 (0.2)4.3 (0.3)*
Severity of impact on daily life6.9 (0.3)6.7 (0.4)6.3 (0.5)
No of days abdominal pain5.4 (0.2)5.4 (0.2)4.7 (0.3)*
Severity of abdominal pain7.5 (0.3)7.5 (0.3)6.4 (0.6)
Worst episode of abdominal pain8.5 (0.3)8.4 (0.3)6.7 (0.7)*
No of days bloating4.9 (0.3)4.8 (0.3)4.2 (0.4)*
Severity of bloating6.2 (0.5)6.2 (0.5)5.1 (0.6)*
Worst episode of bloating7.3 (0.6)7.1 (0.6)6.3 (0.6)*
Severity of stool problems6.3 (0.5)6.4 (0.5)6.3 (0.6)
No of days with loose stools2.7 (0.4)2.9 (0.4)2.6 (0.4)
No of days with hard stools2.0 (0.4)2.0 (0.4)2.0 (0.4)
No of days with urgency2.6 (0.3)2.6 (0.4)2.4 (0.4)
No of days with straining2.9 (0.4)2.7 (0.4)2.5 (0.4)*
No of days with incomplete evacuation3.3 (0.4)3.2 (0.41)3.1 (0.4)