Table 6.5

Placebo controlled trials of azathioprine for maintenance of medically induced remission in Crohn’s disease

AuthorYearNumber of patientsDose
>(mg/kg/day)
Duration (months)Relapse rate (%)Ref section 2
AzathioprinePlacebop Value
*Remission while receiving azathioprine >42 months.
Willoughby197110262060<0.05139
Rosenberg197520292050<0.01140
O’Donoghue197851212541<0.05141
Summers (NCCDS) (1st part)1979192.591625NS96
Summers (NCCDS) (2nd part)197454124NS
Candy1995432.5125893<0.001142
Lémann (GETAID)200283*1.718821NS (non-inferiority design)69, 143