Allele frequencies and carriage rates for variants in the IBD5 haplotype in patients with ulcerative colitis compared with healthy controls
| Allelic frequency | UC patients (n = 74) v | p Value | Odds ratio |
|---|---|---|---|
| healthy controls (n = 256) | |||
| Three marker single nucleotide polymorphisms (SNPs) (IGR2096a_1, IGR2198a_1, and IGR2230a_1) were used to represent the IBD5 haplotype together with two SNPs in the OCTN1 and 2 (1672C→T and −207G→C, respectively). The SNP IGR2198a_1 was associated with susceptibility to ulcerative colitis. Homozygous carriage both of the SNPs IGR2096a_1 and IGR2198a_1 and of the TC and IBD5 haplotype was associated with susceptibility to ulcerative colitis. The results for heterozygous carriage all failed to achieve significance (results not shown). | |||
| UC, ulcerative colitis. | |||
| IGR2096a_1 | 50.7% v 42.0% | 0.07 | 1.42 (0.97 to 2.08) |
| IGR2198a_1 | 50.7% v 41.0% | 0.04 | 1.48 (1.02 to 2.15) |
| IGR2230a_1 | 52.9% v 47.5% | 0.25 | 1.24 (0.85 to 1.81) |
| OCTN1 | 52.1% v 42.9% | 0.05 | 1.45 (1.00 to 2.10) |
| OCTN2 | 54.1% v 47.9% | 0.18 | 1.28 (0.89 to 1.86) |
| Homozygous carriers | |||
| IGR2096a_1 | 27.9% v 15.2% | 0.01 | 2.16 (1.15 to 4.05) |
| IGR2198a_1 | 26.8% v 15.2% | 0.04 | 1.92 (1.03 to 3.58) |
| IGR2230a_1 | 27.5% v 21.2% | 0.26 | 1.41 (0.77 to 2.60) |
| TC Haplotype | 28.2% v 16.1% | 0.02 | 2.04 (1.10 to 3.78) |
| Combined IBD5 haplotype | 26.6% v 14.7% | 0.02 | 2.10 (1.09 to 4.05) |